University of Manchester Researchers have potentially found the much desired cure for baldness

Reports have stated that a potential new cure for baldness has been discovered using a drug that was originally intended to treat osteoporosis. Researchers found the drug had a dramatic effect on hair follicles in the lab, enabling stimulation for grow.

The treatment contains a compound which targets a protein that acts as a brake on hair growth and plays a role in baldness.

Project leader Dr Nathan Hawkshaw, from the University of Manchester, said it could “make a real difference to people who suffer from hair loss”.

 

The only two drugs currently available to treat balding (androgenetic alopecia) are:

  • minoxidil, for men and women
  • finasteride, for men only

However neither are available on the NHS and both have side-effects and are not always effective, causing patients often resort to hair transplantation surgery instead.

The research, published in PLOS Biology, was done in a lab, with samples containing scalp hair follicles from more than 40 male hair-transplant patients.

The researchers first latched onto an old immunosuppressive drug, cyclosporine A, which has been used since the 1980s, to prevent transplant organ rejection and reduce symptoms of autoimmune disease.

The scientists found that the drug reduced the activity of a protein called SFRP1, a key growth regulator that affects many tissues including hair follicles. Due to its side effects, CsA was unsuitable as a baldness treatment.

The Manchester research team went on to look for another agent that targeted SFRP1 and found that WAY-316606 was even better at suppressing the protein.

Dr Hawkshaw told the BBC that a clinical trial is required to see if the treatment was effective and safe in people.

A British Association of Dermatologists spokesman told the BBC: “This is a very interesting study.

“As the researchers say, hair loss is a common disorder and it can cause considerable damage to emotional health, including loss of self-esteem and confidence.

That said, more research will need to be done before it can be used by people with hair loss.

“For individuals with hair loss, treatments can be very hit and miss. There isn’t one which is universally effective.

For that reason new treatments are exciting as they give people more treatment options that may be effective.”

Source: BBC News

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